Scientific References

• Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome
• Selective Pro Resolving Mediators, Harvard Review Article, 2016
• Selective Pro Resolving Mediators, possible role in COVID treatment, 2021
• Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial Osteoporosis has become a leading cause of morbidity and mortality worldwide and is an ever-increasing drain on healthcare resources. Osteoporosis is defined as progressive skeletal disorder, characterised by low bone mass (osteopenia) and micro-architectural deterioration, resulting in an increase in bone fragility and increased risk to factures [1].
• Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. New England Journal of Medicine, 2008
• Effects of low glycemic diet on resting energy expenditure and heart disease risk factors during weight loss. Journal of American Medical Association, 2004
• Adiposity as compared with physical activity in predicting mortality among women. New England Journal of Medicine, 2004
• A clinical trial of the effects of dietary patterns on high blood pressure. New England Journal of Medicine, 1997
• Effects of comprehensive lifestyle modification on blood pressure control. Journal of American Medical Association, 2003
• Effect of comprehensive therapeutic lifestyle changes on prehypertension. American Journal of Cardiology, 2008
• Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. British Journal of Nutrition, 2010
• Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
• Probiotics improve outcomes after roux-en-Y gastric bypass: A prospective randomized trial. Journal of Gastrointestinal Surgery 2009
• Reduction in the incidence of type-2 diabetes with lifestyle intervention or metformin. New England Journal of Medicine, 2002
• Changes in diet and lifestyle and long-term weight gain in women and men. New England Journal of Medicine, 2011
• Prevention of type-2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine, 2001
• Adherence to a mediterranean diet and survival in a greek population. New England Journal of Medicine, 2003
• Effects of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome. Journal of the American Medical Association, 2004
• Mediterranean diet, lifestyle factors, and 10-year mortality in elderly european men and women. Journal of the American Medical Association, 2004
• US Food and Drug administration, section 5(b) of the Orphan Drug Act: Medical food is “a food which is formulated to be consumed under the supervision of a physician and which is intended for specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.”
• Double-blind, placebo controlled trial examining the effects of RIAA/Acacia supplementation on insulin homeostasis. Functional Medicine Research Center, 2006
• Enhancement of a modified mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial. Nutrition and Metabolism, 2008
• Subjects with elevated LDL cholesterol and metabolic syndrome benefit from supplementation with soy protein, phytosterols, hops rho iso-alpha-acids, and Acacia nilotica proanthocyanidins. Journal of Clinical Lipidology, 2010
• A mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism.  Journal of Clinical Lipidology, 2011
• Eating Nuts Linked to Healthier, Longer Life – Harvard Health Publications
• A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Duke University, 2004
• Persistent Metabolic Adaptation 6 Years AFter “The Biggets Loser” Competition. Obesity Journal, March 2016.

Bibliography for Article and Presentation

“Emerging Concepts in Obesity”

by Robert Woodbury, MD April, 2014

• Centers for Disease Control. Obesity trends 2010
• Ryan, Woods, and Seeley “Central nervous system mechanisms linking consumption of palatable high-fat diets to the defense of greater adiposity” Cell Metab. 2012 Feb 8;15(2) 137-149.
• Seeley et al “Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding.” Am J. PHysiology, Sept 1996 vol 271. 819-823.
• Williams Trust Case Control Consortium. “Genomic-wade association study of 14,000 cases of seven common diseases and 3000 shared controls”. Nature 2007; 447: 661-678
• Frayling et al.  “A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity”.  Science 2007. 316. 889-894
• Cecil JE.  “An obesity associated FTO gene variant and increased energy intake in children”  NEJM 2008: 359: 2558-2566
• Diva, C. “Variation in the FTO contributes to childhood obesity and severe adult obesity”.  Nat. Genet. 2007: 39; 724-726
• Andreasen, CH.  “Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation”.  Diabetes 2008; 57: 95-101
• Hunt, SC. “Association of the FTO gene with BMI”.  Obesity Apr 2008 16(4) 902
• Karra et al. “A link between FTO, ghrelin, and impaired brain food-cue responsivity.”  J. Clin. Inv. Aug 2013 123(8) 3539-3551
• Tamashiro et al.  “Cloned mice have an obese phenotype not transmitted to their offspring.”  Nat Medicine Mar 2002 8(3)
• Smith, Marceau, et al.  “Effects of maternal surgical weight loss in mothers on the intergenerational transmission of obesity”.  J. Clin Endocrinol Metab. 2009 94(11) 4275
• Kral, Marceau et al.  “Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years”.  Pediatric 2006 Dec 118 (6) e1644
• Woodard, Morton, et al.  “Probiotics improve outcomes after Roux-en-Y Gastric Bypass surgery: A prospective randomized trial. “  J. Gastrointest Surgery 2009 13:1198-1204
• Lio, Kaplan et al. “Conserved shifts in gut microbiome due to gastric bypass reduce host weight and adiposity”.  Sci Transl Med 2013 5:178
• Molinaro et al. “Probiotics, prebiotics, energy balance, and obesity”.  Gastroenterol Clin N Am 2012 (41)843-854
• Jumperts  “Energy balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. “  Am J Clin Nutr Jul 2011 94(1):58-65
• Jayasena et al  “Role of gut hormones in obesity”.  Endocrinology and Metabolism Clinics of N AM 2008 37: 769-787
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• Gallwitz and Schmidt  “GLP-1 receptor knock-out causes glucose intolerance but no alterations of eating behavior”.  Z Gastroenterolgy 1997; 35: 655
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• Speaker and Fleshner. “Interleukin-1 Beta: a potential link between stress and the development of visceral obesity. BMC Physiology 2012 12:8
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• Mikalakis and leRoux.  “Gut hormones and leptin: Impact on energy control and changes after bariatric surgery, what the future holds.” Obes Surg 2012 22:1648-1657
• Seeley and Kaplan. Presentation at Metabolic Applied Research Strategy Conference June 2010
• Kaplan. “Effect of surgical and non-surgical weight loss on energy expenditure”. Presentation at Metabolic Applied Research Strategy, June 2012.  Based on much of his own unpublished and published work including: Mirshahi et al “The MC4R Allele is associated with better metabolic status and more weight loss after gastric bypass surgery. J Clin Endocrin Metab Dec 2011; 96(12) E2088-E2096
• Hatoum et al.  “Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery” J. Clin Endocrinolgy Metab 2012
• Periera, et al. “Effects of a low glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. JAMA. Nov 24, 2004. vol 292 #20
• Stylopoulous et al  “Roux-en-Y gastric bypass enhances energy expenditure and extend lifespan in diet-induced obese rats”.  Obesity 2009; 17(10): 1839-1847
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Our Favorite Books

• “Eat Drink and be Healthy” Walt Willett
• “KMD: Ketogenic Mediterranean Diet” Steve Parker
• “Omnivore’s Dilemma” Michael Pollan
• “Bloog Sugar Solution” Mark Hyman
• “Wheat Belly” William Davis
• “Changing for Good”
• “Food, Inc.” Karl Weber

Our Favorite Cookbooks

• “Practical Paleo” Diane Sanfilippo
• “Against All Grain” Danielle Walker
• “Nom Nom Paleo” Michelle Tam